NALP10 Antibody

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ProSci
Product Code: PSI-5967
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5967-0.02mg0.02mg£150.00
Quantity:
PSI-5967-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at 1 μg/mL.
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Immunohistochemistry of NALP10 in human brain tissue with NALP10 antibody at 10 μg/mL.
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Immunofluorescence of NALP10 in human brain tissue with NALP10 antibody at 20 μg/mL.
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Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at 1 μg/mL.
Immunohistochemistry of NALP10 in human brain tissue with NALP10 antibody at 10 μg/mL.
Immunofluorescence of NALP10 in human brain tissue with NALP10 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
NALP10 Antibody: NOD8, PAN5, PYNOD, NALP10, CLR11.1, NOD8, NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8
Application Note:
NALP10 antibody can be used for detection of NALP10 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NALP10 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1β, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1β processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
Background References:
  • Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
  • Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
  • Wang Y, Hasegawa M, Imamura R, et al. PYNOD,a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. Int. Immunol.2004; 16:777-86.
  • Imamura R, Wang Y, Kinoshita T, et al. Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J. Immunol.2010; 184:5874-84.
Buffer:
NALP10 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (83%)
Immunogen:
NALP10 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human NALP10.

The immunogen is located within the first 50 amino acids of NALP10.
NCBI Gene ID #:
338322
NCBI Official Name:
NLR family, pyrin domain containing 10
NCBI Official Symbol:
NLRP10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_789791
Protein GI Number:
28827807
Purification:
NALP10 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q86W26
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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