NALP12 Antibody

Contact us
ProSci
Product Code: PSI-5971
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5971-0.02mg0.02mg£150.00
Quantity:
PSI-5971-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

1 / 3
Western blot analysis of NALP12 in human brain tissue lysate with NALP12 antibody at 1 μg/mL.
2 / 3
Immunohistochemistry of NALP12 in human brain tissue with NALP12 antibody at 5 μg/mL.
3 / 3
Immunofluorescence of NALP12 in human brain tissue with NALP12 antibody at 20 μg/mL.
❮❯

Western blot analysis of NALP12 in human brain tissue lysate with NALP12 antibody at 1 μg/mL.
Immunohistochemistry of NALP12 in human brain tissue with NALP12 antibody at 5 μg/mL.
Immunofluorescence of NALP12 in human brain tissue with NALP12 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
NALP12 Antibody: RNO, PAN6, RNO2, FCAS2, NALP12, PYPAF7, CLR19.3, RNO, NACHT, LRR and PYD domains-containing protein 12, Monarch-1
Application Note:
NALP12 antibody can be used for detection of NALP12 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NALP12 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-κB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Background References:
  • Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
  • Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
  • Williams KL, Lich JD, Duncan JA, et al. The CATERPILLER protein Monarch-1 is an antagonist of toll-like receptor- , tumor necrosis factor a-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J. Biol. Chem.2005; 48:39914-24.
  • Jeru I, Duquesnoy P, Fernandes-Alnemri T, et al. Mutations in NALP12 cause hereditary periodic fever syndromes. Proc. Natl. Acad. Sci. USA2008; 105:1614-9.
Buffer:
NALP12 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NALP12 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP12.

The immunogen is located within amino acids 110 - 160 of NALP12.
NCBI Gene ID #:
91662
NCBI Official Name:
NLR family, pyrin domain containing 12
NCBI Official Symbol:
NLRP12
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_653288
Protein GI Number:
21955154
Purification:
NALP12 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
P59046
User NOte:
Optimal dilutions for each application to be determined by the researcher.

Related Products

Product NameProduct CodeSupplier 
NALP12 PeptidePSI-5971PProSci Summary Details