MOX1 Antibody

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ProSci
Product Code: PSI-5995
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5995-0.02mg0.02mg£150.00
Quantity:
PSI-5995-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of MOX1 in human liver tissue lysate with MOX1 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunohistochemistry of MOX1 in rat liver tissue with MOX1 antibody at 10 μg/mL.
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Immunofluorescence of MOX1 in rat liver tissue with MOX1 antibody at 20 μg/mL.
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Western blot analysis of MOX1 in human liver tissue lysate with MOX1 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of MOX1 in rat liver tissue with MOX1 antibody at 10 μg/mL.
Immunofluorescence of MOX1 in rat liver tissue with MOX1 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
MOX1 Antibody: KFS2, MOX1, Homeobox protein MOX-1, Mesenchyme homeobox 1
Application Note:
MOX1 antibody can be used for detection of MOX1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
MOX1 Antibody: MOX1, also known as MEOX1, is a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes that is first expressed during gastrulation in the early mesoderm and later in presomitic mesoderm, early somites, dermomyotome and sclerotome. Both MOX1 and the related protein MOX2 are required for proper gene expression in all somitic compartments. MOX1 is an upstream regulator of the transcription factors Bapx1, Tbx18, and Uncx and is thus part of a regulatory circuit that functions in the maintenance of rostrocaudal sclerotome polarity and axial skeleton formation.
Background References:
  • Cadia AF, Hu J, Crosby J, et al. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development1992; 116:1123-36.
  • Candia AF and Wright CV. Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. Int. J. Dev. Biol.1996; 40:1179-84.
  • Mankoo BS, Skuntz S, Harrigan I, et al. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning, and differentiation of somites. Development2003; 130:4655-64.
  • Skuntz S, Mankoo B, Nguyen MT, et al. Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the craniocervical joints of the axial skeleton. Dev. Biol.2009; 332:383-95.
Buffer:
MOX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MOX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human MOX1.

The immunogen is located within amino acids 140 - 190 of MOX1.
NCBI Gene ID #:
4222
NCBI Official Name:
mesenchyme homeobox 1
NCBI Official Symbol:
MEOX1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_004518
Protein GI Number:
4758710
Purification:
MOX1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
P50221
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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