STAU1 Antibody
| Code | Size | Price |
|---|
| PSI-5997-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5997-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
STAU1 Antibody: STAU, STAU, Double-stranded RNA-binding protein Staufen homolog 1
Application Note:
STAU1 antibody can be used for detection of STAU1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
STAU1 Antibody: STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.
Background References:
- Marion RM, Fortes P, Peloso A, et al. A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Mol. Cell. Biol.1999; 19:2212-9.
- de Lucas S, Peredo J, Marion RM, et al. Human Staufen1 protein interacts with influenza virus nucleoproteins and is required for efficient virus multiplication. J. Virol.2010; 84:7603-12.
Buffer:
STAU1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
STAU1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human STAU1.
The immunogen is located within the last 50 amino acids of STAU1.
The immunogen is located within the last 50 amino acids of STAU1.
NCBI Gene ID #:
6780
NCBI Official Name:
staufen, RNA binding protein, homolog 1 (Drosophila)
NCBI Official Symbol:
STAU1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_059347
Protein GI Number:
82659087
Purification:
STAU1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
O95793
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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