ZNF346 Antibody
| Code | Size | Price |
|---|
| PSI-6003-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6003-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZNF346 Antibody: JAZ, Zfp346, JAZ, Zinc finger protein 346, Just another zinc finger protein
Application Note:
ZNF346 antibody can be used for detection of ZNF346 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
ZNF346 Antibody: ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.
Background References:
- Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
- Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep.2000; 1:287-92.
- Yang M, May WS, and Ito T. JAZ requires the double-stranded RNA-binding zinc-finger motifs for nuclear localization. J. Biol. Chem.1999; 274: 27399-406.
- Chen T, Brownawell AM, and Macara IG. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for Exportin 5. Mol. Cell. Biol.2004; 24:6608-19.
Buffer:
ZNF346 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZNF346 antibody was raised against a 20 amino acid synthetic peptide near the amino terminus of human ZNF346.
The immunogen is located within amino acids 70 - 120 of ZNF346.
The immunogen is located within amino acids 70 - 120 of ZNF346.
NCBI Gene ID #:
23567
NCBI Official Name:
zinc finger protein 346
NCBI Official Symbol:
ZNF346
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_036411
Protein GI Number:
6912440
Purification:
ZNF346 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q9UL40
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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