PLAC1 Antibody
| Code | Size | Price |
|---|
| PSI-6015-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6015-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PLAC1 Antibody: CT92, OOSP2L, Placenta-specific protein 1
Application Note:
PLAC1 antibody can be used for detection of PLAC1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PLAC1 Antibody: PLAC1 was initially identified as a protein expressed specifically in the placenta and other cells derived from the trophoblast lineage during embryonic development, but has also been found to be expressed ectopically in a wide range of human malignancies, particularly breast cancers. PLAC1 is a membrane-associated protein that is thought to serve a receptor-like function modulating cell-cell or ligand receptor interactions unique to the maternal-placental interface. Decreased expression of PLAC1 is associated with decreased expression of cyclin D1 and reduced expression of AKT kinase, which, combined with the fact that PLAC1 is expressed on the surface of cancer cells, suggests that PLAC1 may be an effective candidate for immunotherapeutic treatments of cancer.
Background References:
- Cocchia M, Humber R, Pantano S, et al. PLAC1, an Xq26 gene with placenta-specific expression. Genomics2000; 68:305-12.
- Koslowski M, Sahin U, Mitnacht-Kraus R, et al. A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes. Cancer Res.2007; 67:9528-34.
- Fant M, Weisoly DL, Cocchia M, et al. PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. Mol. Reprod. Dev.2002; 63:430-6.
Buffer:
PLAC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PLAC1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human PLAC1.
The immunogen is located within amino acids 130 - 180 of PLAC1.
The immunogen is located within amino acids 130 - 180 of PLAC1.
NCBI Gene ID #:
10761
NCBI Official Name:
placenta-specific 1
NCBI Official Symbol:
PLAC1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_068568
Protein GI Number:
11496283
Purification:
PLAC1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q9HBJ0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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