PLAC4 Antibody

Contact us
ProSci
Product Code: PSI-6021
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6021-0.02mg0.02mg£150.00
Quantity:
PSI-6021-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

1 / 3
Western blot analysis of PLAC4 in human placenta tissue lysate with PLAC4 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunocytochemistry of PLAC4 in HeLa cells with PLAC4 antibody at 10 μg/mL.
3 / 3
Immunofluorescence of PLAC4 in HeLa cells with PLAC4 antibody at 20 μg/mL.
❮❯

Western blot analysis of PLAC4 in human placenta tissue lysate with PLAC4 antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of PLAC4 in HeLa cells with PLAC4 antibody at 10 μg/mL.
Immunofluorescence of PLAC4 in HeLa cells with PLAC4 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
PLAC4 Antibody: PRED78, C21orf115, D21S418E, PP1416, Placenta-specific protein 4
Application Note:
PLAC4 antibody can be used for detection of PLAC4 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PLAC4 Antibody: PLAC4 (placenta-specific protein 4), was initially discovered as a gene whose mRNA was expressed in placental syncytiotrophoblast and choriocarcinoma cells. While the function of PLAC4 is currently unclear, its gene is known to be located on chromosome 21q22.3. Due to the PLAC4 gene location on chromosome 21 and the release of its mRNA transcripts into maternal bloodstream from the placenta, it has been proposed to be a useful marker noninvasive prenatal chromosome 21 aneuploidy detection, although other reports suggests that PLAC4 mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21.
Background References:
  • Kido S, Sakuragi N, Bronner MP, et al. D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma. Genomics1993; 17:256-9.
  • Lo YMD, Tsui NBY, Chiu RWK, et al. Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat. Med.2007; 13:218-223.
  • Tsui NB, Akolekar R, Chiu RW, et al. Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. Clin. Chem.2010; 56:73-81.
  • Banzola I, Rusterholz C, Zannoni L, et al. PLAC4 and beta-HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21. Prenat. Diagn.2008; 28:1262-7.
Buffer:
PLAC4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PLAC4 antibody was raised against a 17 amino acid synthetic peptide near the center of human PLAC4.

The immunogen is located within amino acids 20 - 70 of PLAC4.
NCBI Gene ID #:
191585
NCBI Official Name:
placenta-specific 4
NCBI Official Symbol:
PLAC4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_878252
Protein GI Number:
121949815
Purification:
PLAC4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q8WY50
User NOte:
Optimal dilutions for each application to be determined by the researcher.

Related Products

Product NameProduct CodeSupplier 
PLAC4 PeptidePSI-6021PProSci Summary Details