MFSD2A Antibody

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ProSci
Product Code: PSI-6025
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6025-0.02mg0.02mg£150.00
Quantity:
PSI-6025-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of MFSD2A in rat lung tissue lysate with MFSD2A antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of MFSD2A in mouse lung tissue with MFSD2A antibody at 2.5 μg/ml.
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Immunofluorescence of MFSD2A in Rat Lung cells with MFSD2A antibody at 20 μg/mL.
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Immunohistochemistry of MFSD2A in rat lung tissue with MFSD2A antibody at 5 μg/mL.
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Immunofluorescence of MFSD2A in mouse lung tissue with MFSD2A antibody at 20 μg/mL.<br><br>Red: MFSD2A Antibody (6025) <br> Blue: DAPI staining
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Immunohistochemistry of MFSD2A in human brain tissue with MFSD2A antibody at 5 μg/mL.
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Western blot analysis of MFSD2A in rat lung tissue lysate with MFSD2A antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of MFSD2A in mouse lung tissue with MFSD2A antibody at 2.5 μg/ml.
Immunofluorescence of MFSD2A in Rat Lung cells with MFSD2A antibody at 20 μg/mL.
Immunohistochemistry of MFSD2A in rat lung tissue with MFSD2A antibody at 5 μg/mL.
Immunofluorescence of MFSD2A in mouse lung tissue with MFSD2A antibody at 20 μg/mL.<br><br>Red: MFSD2A Antibody (6025) <br> Blue: DAPI staining
Immunohistochemistry of MFSD2A in human brain tissue with MFSD2A antibody at 5 μg/mL.

Documents

Further Information

Additional Names:
MFSD2A Antibody: mfsd2a, zgc:101615, mfsd2a, Major facilitator superfamily domain-containing protein 2A-A
Application Note:
MFSD2A antibody can be used for detection of MFSD2A by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples; Immunohistochemistry in human, mouse, and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.
Background:
MFSD2A Antibody: Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.
Background References:
  • Fluman N and Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim. Biophys. Acta.2009; 1794:738-47.
  • Law CJ, Maloney PC, and Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol.2008; 62:289-305.
  • Spinola M, Falvella FS, Colombo F, et al. MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment. Mol. Cancer2010;9:62.
  • Angers M, Uldry M, Kong D, et al. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem. J.2008; 416:347-55.
Buffer:
MFSD2A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MFSD2A antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human MFSD2A.

The immunogen is located within the last 50 amino acids of MFSD2A.
NCBI Gene ID #:
492810
NCBI Official Name:
major facilitator superfamily domain containing 2aa
NCBI Official Symbol:
mfsd2aa
NCBI Organism:
Danio rerio
Physical State:
Liquid
Protein Accession #:
NP_001129965
Protein GI Number:
55925395
Purification:
MFSD2A Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q5U3U7
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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