MFSD2B Antibody
| Code | Size | Price |
|---|
| PSI-6027-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6027-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
MFSD2B Antibody: Major facilitator superfamily domain-containing protein 2B
Application Note:
MFSD2B antibody can be used for detection of MFSD2B by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
MFSD2B Antibody: Multidrug transporters, such as MFSD2B, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2B is closely related to MFSD2A, which is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting, playing a major role in the induction of MFSD2A expression during adaptive thermogenesis. Unlike MFSD2A, MFSD2B is expressed in few tissues and at relatively low levels, and is not induced during fasting, suggesting that MFSD2B may play other roles.
Background References:
- Fluman N and Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim. Biophys. Acta.2009; 1794:738-47.
- Law CJ, Maloney PC, and Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol.2008; 62:289-305.
- Angers M, Uldry M, Kong D, et al. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem. J.2008; 416:347-55
Buffer:
MFSD2B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (80%)
Immunogen:
MFSD2B antibody was raised against a 15 amino acid synthetic peptide near the center of human MFSD2B.
The immunogen is located within amino acids 240 - 290 of MFSD2B.
The immunogen is located within amino acids 240 - 290 of MFSD2B.
NCBI Gene ID #:
388931
NCBI Official Name:
major facilitator superfamily domain containing 2B
NCBI Official Symbol:
MFSD2B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001073942
Protein GI Number:
122937339
Purification:
MFSD2B Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
A6NFX1
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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