SYNPO2L Antibody
| Code | Size | Price |
|---|
| PSI-6053-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6053-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SYNPO2L Antibody: Synaptopodin 2-like protein
Application Note:
SYNPO2L antibody can be used for detection of SYNPO2L by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
SYNPO2L Antibody: SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.
Background References:
- Beqqali A, Kloots J, Ward-van Oostward D, et al. Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. Stem Cells2006; 24:1956-67.
- Beqqali A, Manshouwer-Kloots J, Moneiro R, et al. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J. Cell Sci.2010; 123:1141-50.
Buffer:
SYNPO2L Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SYNPO2L antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human SYNPO2L.
The immunogen is located within amino acids 140 - 190 of SYNPO2L.
The immunogen is located within amino acids 140 - 190 of SYNPO2L.
NCBI Gene ID #:
79933
NCBI Official Name:
synaptopodin 2-like
NCBI Official Symbol:
SYNPO2L
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
BAD37139
Protein GI Number:
51534920
Purification:
SYNPO2L Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q9H987
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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