PEAR1 Antibody
| Code | Size | Price |
|---|
| PSI-6055-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6055-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PEAR1 Antibody: JEDI, MEGF12, Platelet endothelial aggregation receptor 1, Multiple epidermal growth factor-like domains protein 12, hPEAR1
Application Note:
PEAR1 antibody can be used for detection of PEAR1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PEAR1 Antibody: Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.
Background References:
- Nanda N, Bao M, Lin H, et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in the platelet contact-induced activation. J. Biol. Chem.2005; 280:24680-9.
- Herrera-Galeano JE, Becker DM, Wilson AF, et al. A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregabili. Arterioscler. Thromb. Vasc. Biol.2008; 28:1484-90.
Buffer:
PEAR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PEAR1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PEAR1.
The immunogen is located within the last 50 amino acids of PEAR1.
The immunogen is located within the last 50 amino acids of PEAR1.
NCBI Gene ID #:
375033
NCBI Official Name:
platelet endothelial aggregation receptor 1
NCBI Official Symbol:
PEAR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001073940
Protein GI Number:
122937343
Purification:
PEAR1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q5VY43
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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