SHISA9 Antibody
| Code | Size | Price |
|---|
| PSI-6057-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6057-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SHISA9 Antibody: CKAMP44, Protein shisa-9
Application Note:
SHISA9 antibody can be used for detection of SHISA9 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SHISA9 Antibody: Shisa proteins are a recently-identified family of modulators of both FGF and Wnt signaling that block both maturation and transport to the cell surface of their respective receptors. SHISA9, also known as CKAMP44a, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. It is thought to modulate short-term plasticity at specific excitatory synapses.
Background References:
- Hedge TA and Mason I. Expression of Shisa2, a modulator of both Wnt and Fgf signaling, in the chick embryo. Int. J. Dev. Biol.2008; 52:81-5.
- Von Engelhardt J, Mack V, Sprengel R, et al. CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science2010; 327:1518-22.
- O'Donovan MC, Craddock N, Norton N, et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat. Genet.2008; 40:1053-5.
Buffer:
SHISA9 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SHISA9 antibody was raised against a 22 amino acid synthetic peptide near the center of human SHISA9.
The immunogen is located within amino acids 120 - 170 of SHISA9.
The immunogen is located within amino acids 120 - 170 of SHISA9.
NCBI Gene ID #:
729993
NCBI Official Name:
shisa homolog 9 (Xenopus laevis)
NCBI Official Symbol:
SHISA9
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001138676
Protein GI Number:
291463300
Purification:
SHISA9 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
B4DS77
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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