EFCAB4A Antibody
| Code | Size | Price |
|---|
| PSI-6043-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6043-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
EFCAB4A Antibody: CRACR2B, CRACR2B, EF-hand calcium-binding domain-containing protein 4A, Calcium release-activated calcium channel regulator 2B, CRAC channel regulator 2B
Application Note:
EFCAB4A antibody can be used for detection of EFCAB4A by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
EFCAB4A Antibody: EFCAB4A, also known as Calcium release-activated calcium channel regulator 2B, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation, but the detailed function is still under investigation. It is likely to play a similar role as the related protein EFCAB4B, which acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration.
Background References:
- Srikanth S, Jung HJ, Kim KD, et al. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat. Cell. Biol.2010; 12:436-46.
- Srikanth S, Jung HJ, Ribalet B, et al. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J. Biol. Chem.2010; 285:5066-75.
- Maruyama K, Mikawa T, and Ebashi S. Detection of calcium binding proteins by 45Ca autoradiography on nitrocellulose membrane after sodium dodecyl sulfate gel electrophoresis. J. Biochem.1984; 95:511-9.
Buffer:
EFCAB4A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
EFCAB4A antibody was raised against a 15 amino acid synthetic peptide near the center of human EFCAB4A.
The immunogen is located within amino acids 290 - 340 of EFCAB4A.
The immunogen is located within amino acids 290 - 340 of EFCAB4A.
NCBI Gene ID #:
283229
NCBI Official Name:
EF-hand calcium binding domain 4A
NCBI Official Symbol:
EFCAB4A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_775855
Protein GI Number:
150170653
Purification:
EFCAB4A Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
Swissprot #:
Q8N4Y2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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