ZIP2 Antibody
| Code | Size | Price |
|---|
| PSI-6083-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6083-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZIP2 Antibody: 6A1, ZIP2, ETI-1, ZIP-2, Zinc transporter ZIP2, 6A1
Application Note:
ZIP2 antibody can be used for detection of ZIP2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse and rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse and rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
ZIP2 Antibody: The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.
Background References:
- Gaither LA and Eide DJ. Functional expression of the human hZIP2 zinc transporter. J. Biol. Chem.2000; 275:5560-4.
- Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
- Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
- Kambe T, Geiser J, Lahner B, et al. Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. Am. J. Physiol. Regul. Integr. Comp. Physiol.2008; 294:R1474-81.
Buffer:
ZIP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZIP2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human ZIP2.
The immunogen is located within amino acids 70 - 120 of ZIP2.
The immunogen is located within amino acids 70 - 120 of ZIP2.
NCBI Gene ID #:
29986
NCBI Official Name:
solute carrier family 39 (zinc transporter), member 2
NCBI Official Symbol:
SLC39A2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 34kDa
Observed: 32 kDa
Observed: 32 kDa
Protein Accession #:
NP_055394
Protein GI Number:
156415986
Purification:
ZIP2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q9NP94
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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