ZIP3 Antibody

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ProSci
Product Code: PSI-6085
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6085-0.02mg0.02mg£150.00
Quantity:
PSI-6085-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of ZIP3 in mouse lung tissue lysate with ZIP3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
2 / 2
Immunohistochemistry of ZIP3 in mouse lung tissue with ZIP3 antibody at 5 μg/mL.
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Western blot analysis of ZIP3 in mouse lung tissue lysate with ZIP3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of ZIP3 in mouse lung tissue with ZIP3 antibody at 5 μg/mL.

Documents

Further Information

Additional Names:
ZIP3 Antibody: ZIP3, ZIP-3, ZIP3, Zinc transporter ZIP3, Solute carrier family 39 member 3
Application Note:
ZIP3 antibody can be used for detection of ZIP3 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Background:
ZIP3 Antibody: The zinc transporter ZIP3, also known as SLC39A3, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP2, ZIP3-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.
Background References:
  • Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.
  • Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
  • Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
  • Kambe T, Geiser J, Lahner B, et al. Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. Am. J. Physiol. Regul. Integr. Comp. Physiol.2008; 294:R1474-81.
Buffer:
ZIP3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (94%), Bovine: (88%)
Immunogen:
ZIP3 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP3.

The immunogen is located within amino acids 110 - 160 of ZIP3.
NCBI Gene ID #:
29985
NCBI Official Name:
solute carrier family 39 (zinc transporter), member 3
NCBI Official Symbol:
SLC39A3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_653165
Protein GI Number:
32490561
Purification:
ZIP3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q9BRY0
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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