ZIP13 Antibody

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ProSci
Product Code: PSI-6103
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6103-0.02mg0.02mg£150.00
Quantity:
PSI-6103-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Immunohistochemistry of ZIP13 in human spleen tissue with ZIP13 antibody at 2.5 μg/mL.
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Immunofluorescence of ZIP13 in human spleen tissue with ZIP13 antibody at 20 μg/mL.
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Immunohistochemistry of ZIP13 in human spleen tissue with ZIP13 antibody at 2.5 μg/mL.
Immunofluorescence of ZIP13 in human spleen tissue with ZIP13 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
ZIP13 Antibody: ZIP13, Zinc transporter ZIP13, LIV-1 subfamily of ZIP zinc transporter 9, LZT-Hs9
Application Note:
ZIP13 Antibody can be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
ZIP13 Antibody: The zinc transporter ZIP13, also known as SLC39A13, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP13 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Mutations in ZIP13 have recently been shown to cause a spondylocheiro dysplastic form of Ehlers-Danlos syndrome (SCD-EDS), a generalized skeletal dysplasia involving mainly the spine with clinical abnormalities of the hands in addition to EDS-like features. Other experiments have shown that ZIP13 is required for proper connective tissue development and is involved in BMP/TGF- signaling pathways.
Background References:
  • Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.
  • Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
  • Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
  • Giunta C, Elcioglu NH, Albrecht B, et al. Spondylocheiro dysplastic form of Ehlers-Danlos syndrome - an autosomal recessive entity caused by mutations in the zinc transporter SLC39A13. Am. J. Hum. Genet.2008; 82:1290-305.
Buffer:
ZIP13 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZIP13 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human ZIP13.

The immunogen is located within amino acids 150 - 200 of ZIP13.
NCBI Gene ID #:
91252
NCBI Official Name:
solute carrier family 39 (zinc transporter), member 13
NCBI Official Symbol:
Slc39a13
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001121697
Protein GI Number:
190014617
Purification:
ZIP13 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
At least two isoforms of ZIP13 are known to exist; this antibody will detect both isoforms. ZIP13 antibody is predicted to not cross-react with other ZIP family members.
Swissprot #:
Q96H72
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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