CXXC5 Antibody
| Code | Size | Price |
|---|
| PSI-6111-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6111-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CXXC5 Antibody: CF5, WID, RINF, HSPC195, CXXC-type zinc finger protein 5, Putative MAPK-activating protein PM08, CF5
Application Note:
CXXC5 antibody can be used for detection of CXXC5 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CXXC5 Antibody: CXXC5 is zinc finger protein closely related to the DVL1-binding protein CXXC4 (also known as Idax), and like CXXC4 is thought to modulate the Wnt signaling pathway during development. CXXC5 is upregulated in neural stem cells upon BMP4 stimulation, leading to decreased levels of the Wnt-signaling target AXIN2 and facilitated the response of the stem cells to Wnt3a. Recent reports suggest CXXC5 transcription is activated by the Wilms tumor 1 (WT1) transcription factor, and together are involved in the WNT/beta-catenin pathway and play a role in embryonic kidney development.
Background References:
- Andersson T, Sodersten E, Duckworth JK, et al. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. J. Biol. Chem.2009; 284:3672-81.
- Kim MS, Yoon SK, Bollig F, et al. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. J. Biol. Chem. 2010; 285:14585-93.
Buffer:
CXXC5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
CXXC5 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human CXXC5.
The immunogen is located within amino acids 30 - 80 of CXXC5.
The immunogen is located within amino acids 30 - 80 of CXXC5.
NCBI Gene ID #:
51523
NCBI Official Name:
CXXC finger protein 5
NCBI Official Symbol:
CXXC5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 25, 35 kDa
Observed: 25, 35 kDa
Observed: 25, 35 kDa
Protein Accession #:
NP_057547
Protein GI Number:
158261990
Purification:
CXXC5 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
At least two isoforms of CXXC5 are known to exist. CXXC5 antibody is predicted to not cross-react with other CXXC protein family members.
Swissprot #:
Q7LFL8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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