ZMYM1 Antibody

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ProSci
Product Code: PSI-6133
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6133-0.02mg0.02mg£150.00
Quantity:
PSI-6133-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of ZMYM1 in rat lung tissue lysate with ZMYM1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
2 / 2
Immunohistochemistry of ZMYM1 in rat lung tissue with ZMYM1 antibody at 5 μg/mL.
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Western blot analysis of ZMYM1 in rat lung tissue lysate with ZMYM1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of ZMYM1 in rat lung tissue with ZMYM1 antibody at 5 μg/mL.

Documents

Further Information

Additional Names:
ZMYM1 Antibody: MYM, Zinc finger MYM-type protein 1
Application Note:
ZMYM1 antibody can be used for detection of ZMYM1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Background:
ZMYM1 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM1 is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing. While its function remains unknown, the related protein ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes, suggesting that ZMYM1 may play a similar role.
Background References:
  • Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
  • Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature2006; 441:315-21.
  • Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet.2000; 89:24-8.
  • Gocke CB and Yu H. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One2008; 3:e3255.
Buffer:
ZMYM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZMYM1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZMYM1 .

The immunogen is located within amino acids 990 - 1040 of ZMYM1.
NCBI Gene ID #:
79830
NCBI Official Name:
zinc finger, MYM-type 1
NCBI Official Symbol:
ZMYM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_079048
Protein GI Number:
113205089
Purification:
ZMYM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
At least two isoforms of ZMYM1 are known to exist; this antibody will detect only the shorter isoform. ZMYM1 antibody is predicted to not cross-react with other ZMYM protein family members.
Swissprot #:
Q5SVZ6
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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