ZMYM2 Antibody
| Code | Size | Price |
|---|
| PSI-6135-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6135-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZMYM2 Antibody: FIM, MYM, RAMP, SCLL, ZNF198, FIM, Zinc finger MYM-type protein 2, Fused in myeloproliferative disorders protein
Application Note:
ZMYM2 antibody can be used for detection of ZMYM2 by Western blot at 0. 125 - 0.25 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1). The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3). As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4). Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5).
Background References:
- Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70.
- Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature 2006; 441:315-21.
- Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11q12. Cytogenet. Cell Genet. 2000; 89:24-8
- Gocke CB and Yu H. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One 2008; 3:e3255
Buffer:
ZMYM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZMYM2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ZMYM2.
The immunogen is located within amino acids 120 - 170 of ZMYM2.
The immunogen is located within amino acids 120 - 170 of ZMYM2.
NCBI Gene ID #:
7750
NCBI Official Name:
zinc finger, MYM-type 2
NCBI Official Symbol:
ZMYM2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
CAH71822
Protein GI Number:
300192961
Purification:
ZMYM2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
At least two isoforms of ZMYM2 are known to exist; this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.
Swissprot #:
Q9UBW7
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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