ZMYM3 Antibody

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ProSci
Product Code: PSI-6137
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6137-0.02mg0.02mg£150.00
Quantity:
PSI-6137-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of ZMYM3 in human brain tissue lysate with ZMYM3 antibody at 1 μg/mL.
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Immunofluorescence of ZMYM3 in human brain tissue with ZMYM3 antibody at 20 μg/mL.
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Western blot analysis of ZMYM3 in human brain tissue lysate with ZMYM3 antibody at 1 μg/mL.
Immunofluorescence of ZMYM3 in human brain tissue with ZMYM3 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
ZMYM3 Antibody: MYM, XFIM, ZNF261, DXS6673E, ZNF198L2, KIAA0385, Zinc finger MYM-type protein 3, Zinc finger protein 261
Application Note:
ZMYM3 antibody can be used for detection of ZMYM3 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
ZMYM3 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM3 is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation.
Background References:
  • Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
  • Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature2006; 441:315-21
  • Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet.2000; 89:24-8.
  • van der Maarel SM, Scholten IH, Huber I, et al. Cloning and characterization of DSX6673E, a candidate gene for X-linked mental retardation in Xq13.1. Hum. Mol. Gen.1996; 5:887-97.
Buffer:
ZMYM3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZMYM3 antibody was raised against a 18 amino acid synthetic peptide near the center of human ZMYM3.

The immunogen is located within amino acids 220 - 270 of ZMYM3.
NCBI Gene ID #:
9203
NCBI Official Name:
zinc finger, MYM-type 3
NCBI Official Symbol:
ZMYM3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAH69057
Protein GI Number:
119625706
Purification:
ZMYM3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
At least three isoforms of ZMYM3 are known to exist; this antibody will detect all three. ZMYM3 antibody is predicted to not cross-react with other ZMYM protein family members.
Swissprot #:
Q14202
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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