LRRTM1 Antibody
| Code | Size | Price |
|---|
| PSI-6167-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6167-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
LRRTM1 Antibody: Leucine-rich repeat transmembrane neuronal protein 1
Application Note:
LRRTM1 antibody can be used for detection of LRRTM1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
LRRTM1 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM1 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.
Background References:
- Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21.
- Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49.
- Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506.
- Haines BP and Rigby PW. Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr. Patterns 2007; 7:23-9.
Buffer:
LRRTM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
LRRTM1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LRRTM1.
The immunogen is located within amino acids 450 - 500 of LRRTM1.
The immunogen is located within amino acids 450 - 500 of LRRTM1.
NCBI Gene ID #:
347730
NCBI Official Name:
leucine rich repeat transmembrane neuronal 1
NCBI Official Symbol:
LRRTM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAH45113
Protein GI Number:
86990456
Purification:
LRRTM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
LRRTM1 antibody is predicted to not cross-react with other LRRTM family members.
Swissprot #:
Q86UE6
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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