VPS39 Antibody
| Code | Size | Price |
|---|
| PSI-6183-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6183-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
VPS39 Antibody: TLP, VAM6, hVam6p, KIAA0770, TLP, TRAP1-like protein
Application Note:
VPS39 antibody can be used for detection of VPS39 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.
Background:
VPS39 Antibody: VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6.5.
Background References:
- Nakamura N, Hirata A, Ohsumi Y, et al. Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 1997; 272:11344-9.
- Caplan S, Hartnell LM, Aguilar RC, et al. Human Vam6p promotes lysosome clustering and fusion in vivo. J. Cell Biol. 2001; 154:109-22.
- Felici A, Wurthner JU, Parks WT, et al. TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J. 2003; 22:4465-77.
- Messler S, Kropp S, Episkopou V, et al. The TGF-b signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development. Immunobiology 2011; 216:343-50.
Buffer:
VPS39 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
VPS39 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human VPS39.
The immunogen is located within amino acids 710 - 760 of VPS39.
The immunogen is located within amino acids 710 - 760 of VPS39.
NCBI Gene ID #:
23339
NCBI Official Name:
vacuolar protein sorting 39 homolog (S. cerevisiae)
NCBI Official Symbol:
VPS39
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAQ05978
Protein GI Number:
54234024
Purification:
VPS39 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
At least four isoforms of VPS39 are known to exist; this antibody will detect all four. VPS39 antibody is predicted not to cross-react with TRAP1.
Swissprot #:
Q96JC1
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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