ZNF346 (CT) Antibody
| Code | Size | Price |
|---|
| PSI-6209-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6209-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZNF346 (CT) Antibody: JAZ, Zfp346, JAZ, Zinc finger protein 346, Just another zinc finger protein
Application Note:
ZNF346 antibody can be used for detection of ZNF346 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
ZNF346 (CT) Antibody: ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.
Background References:
- Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70.
- Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep. 2000; 1:287-92.
- Yang M, May WS, and Ito T. JAZ requires the double-stranded RNA-binding zinc-finger motifs for nuclear localization. J. Biol. Chem. 1999; 274: 27399-406.
- Chen T, Brownawell AM, and Macara IG. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for Exportin 5. Mol. Cell. Biol. 2004; 24:6608-19.
Buffer:
ZNF346 (CT) Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZNF346 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human ZNF346.
The immunogen is located within the last 50 amino acids of ZNF346.
The immunogen is located within the last 50 amino acids of ZNF346.
NCBI Gene ID #:
23567
NCBI Official Name:
zinc finger protein 346
NCBI Official Symbol:
ZNF346
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_036411
Protein GI Number:
6912440
Purification:
ZNF346 (CT) Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
ZNF346 antibody is predicted to not cross-react with other ZNF family members. Three isoforms of ZNF346 are known to exist; this antibody will recognize the two longest isoforms
Swissprot #:
Q9UL40
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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