BAPX1 Antibody
| Code | Size | Price |
|---|
| PSI-6211-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6211-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
BAPX1 Antibody: SMMD, BAPX1, NKX3B, NKX3.2, Bagpipe homeobox protein homolog 1
Application Note:
BAPX1 antibody can be used for detection of BAPX1 by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
BAPX1 Antibody: BAPX1 is the mammalian homolog of the Drosophila bagpipe homeobox gene and is expressed in the splanchnic mesoderm and embryonic skeleton. It is one of the earliest developmental markers for the sclerotome portion of the somite and the gut mesentery. BAPX1 is required for normal skeletal development; homozygous inactivating mutations in the BAPX1 gene result in spodylo-megaepiphyseal-metaphyseal dysplasia (SMMD). It has also been suggested to play a role in the proper development of the mammalian gut and is required for distal stomach development as part of a BARX1-dependent pathway.
Background References:
- Tribioli C, Frasch M, and Lufkin T. Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton. Mech. Dev. 1997; 65:145-62.
- Hellemans J, Simon M, Dheedene A, et al. Homozygous inactivating mutations in the NKX3-2 gene result in spodylo-megaepiphyseal-metaphyseal dysplasia. Am. J. Hum. Genet. 2009; 85:916-22.
- Verzi MP, Stanfel MN, Moses KA, et al. Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology 2009; 136:1701-10.
Buffer:
BAPX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BAPX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human BAPX1.
The immunogen is located within amino acids 180 - 230 of BAPX1.
The immunogen is located within amino acids 180 - 230 of BAPX1.
NCBI Gene ID #:
579
NCBI Official Name:
NK3 homeobox 2
NCBI Official Symbol:
NKX3-2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001180
Protein GI Number:
4502365
Purification:
BAPX1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
BAPX1 antibody is predicted not to cross-react with other NKX homeobox proteins.
Swissprot #:
P78367
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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