SLAMF1 Antibody
| Code | Size | Price |
|---|
| PSI-6247-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6247-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SLAMF1 Antibody: SLAM, CD150, CDw150, SLAM, Signaling lymphocytic activation molecule
Application Note:
SLAMF1 antibody can be used for detection of SLAMF1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SLAMF1 Antibody: The signaling lymphocyte-activation molecule family member 1 (SLAMF1) is a novel receptor on T cells that potentiates T cell expansion in a CD28-independent manner. SLAMF1 is predominantly expressed by hematopoietic tissues. Reports suggest that the extracellular domain of SLAMF1 is the receptor for the measles virus and acts as a co-activator on both T and B cells. It is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations of the SLAM associated gene may be associated with X-linked lympho-proliferative disease (XLP).
Background References:
- Cocks BG, Chang CC, Carballido JM, et al. 1995. A novel receptor involved in T cell activation. Nature 1995; 376:260-3.
- Tatsuo H, Ono N, Tanaka K, et al. SLAM (CDw150) is a cellular receptor for measles virus. Nature 2000; 406:893-7.
- Aversa G, Chang CC, Carballido JM, et al. Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, Cyclosporin A-sensitive T cell proliferation and IFN-α production. J. Immunol. 1997; 158:4036-44.
Buffer:
SLAMF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SLAMF1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SLAMF1.
The immunogen is located within amino acids 30 - 80 of SLAMF1.
The immunogen is located within amino acids 30 - 80 of SLAMF1.
NCBI Gene ID #:
6504
NCBI Official Name:
signaling lymphocytic activation molecule family member 1
NCBI Official Symbol:
SLAMF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_003028
Protein GI Number:
4506969
Purification:
SLAMF1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
Two isoforms of SLAMF1 are known to exist; this antibody will recognize both isoforms. SLAMF1 antibody is predicted to not cross-react with other SLAM protein family members.
Swissprot #:
Q13291
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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