DYRK1A Antibody

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ProSci
Product Code: PSI-6255
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6255-0.02mg0.02mg£150.00
Quantity:
PSI-6255-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of DYRK1A in HeLa cell lysate with DYRK1A antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of DYRK1A in HeLa cells with DYRK1A antibody at 10 μg/mL.
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Western blot analysis of DYRK1A expression in K562 cell lysate with DYRK1A antibody at (A) 1 and (B) 2 μg/ml.
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Western blot analysis of DYRK1A in HeLa cell lysate with DYRK1A antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of DYRK1A in HeLa cells with DYRK1A antibody at 10 μg/mL.
Western blot analysis of DYRK1A expression in K562 cell lysate with DYRK1A antibody at (A) 1 and (B) 2 μg/ml.

Documents

Further Information

Additional Names:
DYRK1A Antibody: MNB, DYRK, HP86, MNBH, MRD7, DYRK1, MNB, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase
Application Note:
DYRK1A antibody can be used for detection of DYRK1A by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Background:
DYRK1A Antibody: DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
Background References:
  • Park J, Oh Y, and Chung KC. Two key genes closely implicated with the neuropathological characteristics in Down Syndrome: DYRK1A and RCAN1. BMB Reports 2009; 42:6-15.
  • Park J, Oh Y, You L, et al. Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J. Biol. Chem. 2010; 285:31895-906
  • Li D, Jackson RA, Yusoff P, et al. Direct association of Sprouty-related protein with and EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J. Biol. Chem. 2010; 285:35374-85.
Buffer:
DYRK1A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DYRK1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A.

The immunogen is located within the last 50 amino acids of DYRK1A.
NCBI Gene ID #:
1859
NCBI Official Name:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
NCBI Official Symbol:
DYRK1A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 84 kDa

Observed: 90 kDa
Protein Accession #:
NP_001387
Protein GI Number:
18765758
Purification:
DYRK1A Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members
Swissprot #:
Q13627
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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