ZIMP7 Antibody
| Code | Size | Price |
|---|
| PSI-6235-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6235-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZIMP7 Antibody: NET27, ZIMP7, hZIMP7, TRAFIP20, KIAA1886, HRIHFB2007, Zinc finger MIZ domain-containing protein 2, PIAS-like protein Zimp7
Application Note:
ZIMP7 antibody can be used for detection of ZIMP7 by Western blot at 0.25 - 0.5 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
ZIMP7 Antibody: ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR)- mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.
Background References:
- Huang CY, Beliakoff J, Li X, et al. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol. Endocrinol. 2005; 19:2915-29
- Ueki N, Oda T, Kondo M, et al. Selection system for genes encoding nuclear-targeted proteins. Nat. Biotechnol. 1998; 16:1338-42.
- Beliakoff J and Sun Z. Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. Nucl. Recept. Signal. 2006; 4:e017
- Peng Y, Lee J, Zhu C, et al. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. J. Biol. Chem. 2010; 285:11465-75.
Buffer:
ZIMP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZIMP7 antibody was raised against a 17 amino acid synthetic peptide near the center of human ZIMP7.
The immunogen is located within amino acids 270 - 320 of ZIMP7.
The immunogen is located within amino acids 270 - 320 of ZIMP7.
NCBI Gene ID #:
83637
NCBI Official Name:
zinc finger, MIZ-type containing 2
NCBI Official Symbol:
ZMIZ2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q8NF64
Protein GI Number:
54607108
Purification:
ZIMP7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
At least four isoforms are known to exist. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.
Swissprot #:
Q8NF64
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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