SLAMF2 Antibody
| Code | Size | Price |
|---|
| PSI-6249-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6249-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SLAMF2 Antibody: BCM1, BLAST, hCD48, mCD48, BLAST1, SLAMF2, MEM-102, BCM1, CD48 antigen, B-lymphocyte activation marker BLAST-1
Application Note:
SLAMF2 antibody can be used for detection of SLAMF2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
SLAMF2 Antibody: The signaling lymphocyte-activation molecule family member 2 (SLAMF2), also known as CD48, is a GPI-anchored protein that exists as both a soluble and membrane-associated form and is expressed in almost all leukocyte populations particularly in mitogen-stimulated human lymphocytes. SLAMF2 is a high-affinity ligand for SLAMF4, also known as 2B4, as well as a low-affinity ligand for CD2, and can thus can stimulate cells expressing these receptors. It has been shown to be an IL-3-induced activating receptor on eosinophils and is likely to be involved in promoting allergic inflammation. SLAMF2 is also thought to be involved in the IL-18/IL-18R signaling cascade in T and natural killer cells to produce interferon-gamma.
Background References:
- Smith GM, Biggs J, Norris B, et al. Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis. J. Clin. Immunol. 1997; 17:502-9.
- Sidorenko SP and Clark EA. The dual-function CD150 receptor sub-family: the viral attraction. Nat. Immunol. 4:19-24.
- Munitz A, Bachelot I, Eliashar R, et al. CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J. Immunol. 2006; 177:77-83.
- Fukushima K, Ikehara Y, and Yamashita K. Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. J. Biol. Chem. 2005; 280:18056-62.
Buffer:
SLAMF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SLAMF2 antibody was raised against a 19 amino acid synthetic peptide near the center of human SLAMF2.
The immunogen is located within amino acids 90 - 140 of SLAMF2.
The immunogen is located within amino acids 90 - 140 of SLAMF2.
NCBI Gene ID #:
962
NCBI Official Name:
CD48 molecule
NCBI Official Symbol:
CD48
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_1769
Protein GI Number:
21361571
Purification:
SLAMF2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
Two isoforms of SLAMF2 are known to exist; this antibody will recognize both isoforms. SLAMF2 antibody is predicted to not cross-react with other SLAM protein family members.
Swissprot #:
P09326
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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