ORMDL1 Antibody
| Code | Size | Price |
|---|
| PSI-6313-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6313-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ORMDL1 Antibody: ORM1-like protein 1, Adoplin-1
Application Note:
ORMDL1 antibody can be used for detection of ORMDL1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
ORMDL1 Antibody: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.
Background References:
- Hjelmqvist L, Tuson M, Marfany G, et al. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002; 3(6): RESEARCH0027
- Araki W, Takahashi-Sasaki N, Chui DH, et al. A family of membrane proteins associated with Presenilin expression and α-secretase function. FASEB J. 2007; 22: 819-827
- Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473
- Breslow DK, Collins SR, Bodenmiller B, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010; 463(7284):1048-53
Buffer:
ORMDL1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (94%)
Immunogen:
ORMDL1 antibody was raised against a 16 amino acid synthetic peptide of human ORMDL1.
The immunogen is located within amino acids 50 - 100 of ORMDL1.
The immunogen is located within amino acids 50 - 100 of ORMDL1.
NCBI Gene ID #:
94101
NCBI Official Name:
ORM1-like 1 (S. cerevisiae)
NCBI Official Symbol:
ORMDL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_057551
Protein GI Number:
189458852
Purification:
ORMDL1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
ORMDL1 antibody may cross-react with other ORMDL protein family members.
Swissprot #:
Q9P0S3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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