ATAD3B Antibody
| Code | Size | Price |
|---|
| PSI-6389-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6389-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ATAD3B Antibody: TOB3, AAA-TOB3, KIAA1273, TOB3, ATPase family AAA domain-containing protein 3B
Application Note:
ATAD3B antibody can be used for detection of ATAD3B by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
ATAD3B Antibody: ATAD3B is a member of the AAA ATPase family, a family of proteins that catalyze ATP into ADP and are involved in several cellular functions such as cell-cycle regulation, protein proteolysis and transport. The AAA ATPase family is characterized by a highly conserved AAA motif containing Walker homology sequences and imparting ATPase activity. Mitochondrial membrane proteins ATAD3A/B contribute to the stabilization of nucleoids and may participate in the transformation pathway and the chemosensitivity of oligodendrogliomas. The gene encoding ATAD3A/B/C maps to human chromosome 1 and has been suggested to be an anti-apoptotic marker.
Background References:
- Patel S and Latterich M. The AAA team: related ATPases with diverse functions. Trends Cell Biol. 1998; 8:65-71.
- Ogura T and Wilkinson AJ. AAA+ superfamily ATPases: common structure?diverse function. Genes Cells 2001; 6:575-97.
- Hubstenberger A, Labourdette G, Baudier J, et al. ATAD3A and ATAD3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties. Exp. Cell Res. 2008; 314:2870-83
- Fang HY, Chang CL, Hsu SH, et al. ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells. J. Cell Sci. 2010; 123:1171-80.
Buffer:
ATAD3B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ATAD3B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human ATAD3B.
The immunogen is located within amino acids 570 - 620 of ATAD3B.
The immunogen is located within amino acids 570 - 620 of ATAD3B.
NCBI Gene ID #:
83858
NCBI Official Name:
ATPase family, AAA domain containing 3B
NCBI Official Symbol:
ATAD3B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_114127
Protein GI Number:
75677353
Purification:
ATAD3B Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
ATAD3B antibody is predicted to not cross-react with other ATAD protein family members. At least three isoforms of ATAD3B are known to exist.
Swissprot #:
Q5T9A4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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