AP3S1 Antibody
| Code | Size | Price |
|---|
| PSI-6391-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6391-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
AP3S1 Antibody: CLAPS3, Sigma3A, CLAPS3, AP-3 complex subunit sigma-1, AP-3 complex subunit sigma-3A, Sigma3A-adaptin
Application Note:
AP3S1 antibody can be used for detection of AP3S1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
AP3S1 Antibody: AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3 is an heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). AP3S1 Interacts with AGAP1 and may play an important role in carcinoma.
Background References:
- Watanabe TK, Shimizu F, Nagata M, et al. Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain. Cytogenet. Cell Genet. 1996; 73:214-7
- Dell'Angelica EC, Ohno H, Ooi CE, et al. AP-3: an adaptor-like protein complex with ubiquitous expression. EMBO J. 1997; 16:917-28.
- Zhou JB, Yang JK, Zhao L, et al. Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis. Med. Sci. Monit. 2010; 16:BR179-83.
- Petrenko AA, Pavlova LS, Karseladze AI, et al. Downregulation of genes encoding for subunits of adaptor complex-3 in cervical carcinomas. Biochemistry 2006; 71:1153-60
Buffer:
AP3S1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
AP3S1 antibody was raised against a 19 amino acid synthetic peptide near the center of human AP3S1.
The immunogen is located within the first 50 amino acids of AP3S1.
The immunogen is located within the first 50 amino acids of AP3S1.
NCBI Gene ID #:
1176
NCBI Official Name:
adaptor-related protein complex 3, sigma 1 subunit
NCBI Official Symbol:
AP3S1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001275
Protein GI Number:
4502861
Purification:
AP3S1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
At least three isoforms of AP3S1 are known to exist; this antibody will detect the two larger isoforms. AP3S1 antibody is predicted to not cross-react with other AP3 protein family members.
Swissprot #:
Q92572
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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