CCDC141 Antibody
| Code | Size | Price |
|---|
| PSI-6399-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6399-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CCDC141 Antibody: CAMDI, Coiled-coil domain-containing protein 141
Application Note:
CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
Background References:
- Fukuda T, Sugita S, Inatome R, et al. CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J. Biol. Chem. 2010; 285:40554-61.
Buffer:
CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141.
The immunogen is located within amino acids 40 - 90 of CCDC141.
The immunogen is located within amino acids 40 - 90 of CCDC141.
NCBI Gene ID #:
285025
NCBI Official Name:
coiled-coil domain containing 141
NCBI Official Symbol:
CCDC141
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_775919
Protein GI Number:
299829223
Purification:
CCDC141 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
At least four isoforms of CCDC141 are known to exist.
Swissprot #:
Q6ZP82
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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