SYTL5 Antibody
| Code | Size | Price |
|---|
| PSI-6413-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6413-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SYTL5 Antibody: slp5, SLP5, Synaptotagmin-like protein 5
Application Note:
SYTL5 antibody can be used for detection of SYTL5 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Background:
SYTL5 Antibody: SYTL5 belongs to the synaptotagmin-like (Slp) protein family, which contains a unique Slp homolog domain (SHD) at the N-terminus. The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of SYTL5 is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Several members of the synaptotagmin family are calcium-sensing vesicle-fusion proteins as mediators of cell migration. SYTL7 & SYTL5 were positive regulators of chemotaxis, whereas SYTL2 was a negative regulator of chemotaxis.
Background References:
- Kuroda TS, Fukuda M, Ariga H, et al. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem. Biophys. Res. Commun. 2002; 293:899-906.
- Saxena SK, Horiuchi H, and Fukuda M. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. Biochem. Biophys. Res. Commun. 2006; 344:651-7.
- Colvin RA, Means TK, Diefenbach TJ, et al. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat. Immunol. 2010; 11:495-502
- Fukuda M, Mikoshiba K. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Biochem. Biophys. Res. Commun. 2001; 281:1226-33.
Buffer:
SYTL5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SYTL5 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human SYTL5.
The immunogen is located within amino acids 30 - 80 of SYTL5.
The immunogen is located within amino acids 30 - 80 of SYTL5.
NCBI Gene ID #:
94122
NCBI Official Name:
synaptotagmin-like 5
NCBI Official Symbol:
SYTL5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_620135
Protein GI Number:
254039650
Purification:
SYTL5 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
Multiple isoforms of SYTL5 are known to exist. SYTL5 antibody is predicted to not cross-react with other SYTL protein family members.
Swissprot #:
Q8TDW5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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