L1TD1 Antibody
| Code | Size | Price |
|---|
| PSI-6439-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6439-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
L1TD1 Antibody: ECAT11, ECAT11, LINE-1 type transposase domain-containing protein 1, ES cell-associated protein 11
Application Note:
L1TD1 antibody can be used for detection of L1TD1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
L1TD1 Antibody: L1TD1 (ECAT11) is a member of the family of Embryonic Stem Cell Associated Transcripts (ECAT) that play an important role in stem cell biology. ECAT4 (Nanog) is a master regulator for the maintenance of mESC and hESC. ECAT5 was identified to be Embryonic stem cell expressed Ras (ERas), a Ras-like oncogene that is important in regulating mESC proliferation. ECAT9 (GDF3) is an important factor that helps maintain mESC pluripotency by inhibiting bone morphogenetic protein (BMP) signaling. L1TD1 is highly enriched in undifferentiated hESC and L1TD1 is a target gene of Nanog.
Background References:
- Iwabuchi KA, Yamakawa T, Sato Y, et al. ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency. PLoS One. 2011; 6:e20461.
- Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003; 113:631-42
- Takahashi K, Mitsui K, Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 2003; 423:541-5
- Wong RC, Ibrahim A, Fong H, et al. L1TD1 is a marker for undifferentiated human embryonic stem cells. PLoS One 2011;6:e19355.
Buffer:
L1TD1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (76%)
Immunogen:
L1TD1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human L1TD1.
The immunogen is located within amino acids 690 - 740 of L1TD1.
The immunogen is located within amino acids 690 - 740 of L1TD1.
NCBI Gene ID #:
54596
NCBI Official Name:
LINE-1 type transposase domain containing 1
NCBI Official Symbol:
L1TD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_061952
Protein GI Number:
157694505
Purification:
L1TD1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
L1TD1 antibody is predicted to not cross-react with other ECAT protein family members
Swissprot #:
Q5T7N2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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