EIG121 Antibody

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ProSci
Product Code: PSI-6443
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6443-0.02mg0.02mg£150.00
Quantity:
PSI-6443-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of EIG121 in MCF7 cell lysate with EIG121 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunocytochemistry of EIG121 in MCF7 cells with EIG121 antibody at 5 μg/mL.
3 / 3
Immunofluorescence of EIG121 in MCF7 cells with EIG121 antibody at 20 μg/mL.
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Western blot analysis of EIG121 in MCF7 cell lysate with EIG121 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of EIG121 in MCF7 cells with EIG121 antibody at 5 μg/mL.
Immunofluorescence of EIG121 in MCF7 cells with EIG121 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
EIG121 Antibody: EIG, EIG1
Application Note:
EIG121 antibody can be used for detection of EIG121 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
EIG121 Antibody: EIG121 (Estrogen-induced gene 121 protein) is thought to play a role as a marker of hyperestrogenic state and estrogen-related type I endometrial carcinoma. It belongs to the UPF0577 family. It is a 1013 amino acid single-pass transmembrane protein that, though expressed in normal endometrium, is overexpressed in endometriod tumors. As an evolutionarily conserved gene, EIG121 is also expressed during early xenopus development, showing maximum expression at the gastrula stage.
Background References:
  • Deng L, Broaddus RR, McCampbell A, et al. Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer. Clin. Cancer Res. 2005; 11:8258-64.
  • Deng L, Feng J, Broaddus RR. The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress. Cell Death Dis. 2010; 1:e32.
  • Araki T, Kusakabe M and Nishida E. Expression of estrogen induced gene 121-like (EIG121L) during early Xenopus development. Gene Expr. Patterns 2007; 7:666-71.
Buffer:
EIG121 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Immunogen:
EIG121 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human EIG121.

The immunogen is located within the last 50 amino acids of EIG121.
NCBI Gene ID #:
57535
NCBI Official Name:
KIAA1324
NCBI Official Symbol:
KIAA1324
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_065826
Protein GI Number:
38569482
Purification:
EIG121 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
At least four isoforms of EIG121 known to exist. EIG121 antibody is predicted to not cross-react with other UPF0577 protein family members.
Swissprot #:
Q6UXG2
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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