ARHGAP39 Antibody
| Code | Size | Price |
|---|
| PSI-6445-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6445-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ARHGAP39 Antibody: CrGAP, Vilse, KIAA1688, Rho GTPase-activating protein 39
Application Note:
ARHGAP39 antibody can be used for detection of ARHGAP39 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
ARHGAP39 Antibody: Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins. ARHGAP39 (Rho GTPase activating protein 39) is a 1, 083 amino acid nuclear protein that contains one MyTH4 domain, one Rho GAP domain and two WW domains. It is encoded by a gene located on human chromosome 8, which is associated with a variety of diseases and malignancies. ARHGAP39 regulates robo signaling and plays important roles in axon guidance.
Background References:
- Takai Y, Sasaki T, and Matozaki T. Small GTP-binding proteins. Physiol. Rev. 2001; 81:153-208.
- Hu H, Li M, Labrador JP, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc. Natl. Acad. Sci. USA 2005; 102:4613-8
- Nusbaum C, Mikkelsen TS, Zody MC, et al. DNA sequence and analysis of human chromosome 8. Nature 2006; 439:331-5
- Lundström A, Gallio M, Englund C, et al. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 2004; 18:2161-71.
Buffer:
ARHGAP39 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ARHGAP39 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human ARHGAP39.
The immunogen is located within amino acids 880 - 930 of ARHGAP39.
The immunogen is located within amino acids 880 - 930 of ARHGAP39.
NCBI Gene ID #:
80728
NCBI Official Name:
Rho GTPase activating protein 39
NCBI Official Symbol:
ARHGAP39
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_079527
Protein GI Number:
58331179
Purification:
ARHGAP39 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
ARHGAP39 antibody is predicted to not cross-react with other RhoGAP protein family members.
Swissprot #:
Q9C0H5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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