Coronin 7 Antibody
| Code | Size | Price |
|---|
| PSI-6451-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6451-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Coronin 7 Antibody: CRN7, POD1, 0610011B16Rik, Coronin-7, 70 kDa WD repeat tumor rejection antigen homolog, Crn7
Application Note:
Coronin 7 antibody can be used for detection of Coronin 7 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
Coronin 7 Antibody: Coronins, such as Coronin 7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins whose function is thought to be regulating the cytoskeleton. Unlike other cytoplasmically localized Coronins, Coronin 7 localizes in part to the Golgi complex and is thought to play a role in Golgi complex morphology and function. Other experiments indicate that Coronin 7 interacts with the anti-proliferative protein TOB1 and enhances its degradation though the SCF ubiquitin ligase (E3) complex.
Background References:
- Rybakin V, Stumpf N, Schulze A, et al. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. FEBS Lett. 2004; 573:161-7.
- Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. J. Biol. Chem. 2006; 281:31070-8.
- Watanabe M, Suzuki T, Kim M, et al. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 2011; 585:65-70.
Buffer:
Coronin 7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Immunogen:
Coronin 7 antibody was raised against an 17 amino acid synthetic peptide near the carboxy terminus of human Coronin 7.
The immunogen is located within the last 50 amino acids of Coronin 7.
The immunogen is located within the last 50 amino acids of Coronin 7.
NCBI Gene ID #:
79585
NCBI Official Name:
coronin7
NCBI Official Symbol:
CORO7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_078811
Protein GI Number:
168229161
Purification:
Coronin 7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
Multiple isoforms of Coronin 7 are known to exist
Swissprot #:
P57737
User NOte:
Optimal dilutions for each application to be determined by the researcher.
Related Products
| Product Name | Product Code | Supplier |
|---|