UHRF1BP1 Antibody
| Code | Size | Price |
|---|
| PSI-6459-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6459-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
UHRF1BP1 Antibody: ICBP90, C6orf107, dJ349A12.1, UHRF1-binding protein 1, ICBP90-binding protein 1
Application Note:
UHRF1BP1 antibody can be used for detection of UHRF1BP1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
UHRF1BP1 Antibody: The Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1 (UHRF1BP1), also known as ICBP90, is a transcription and cell cycle regulator. It specifically binds to the histone H3 N-terminal tail when methylated on K9 by two functional domains, a PHD finger that defines the binding specificity and an SRA (SET- and RING-associated) domain that promotes binding activity. UHRF1BP1 is required for proper heterochromatin formation in mammalian cells. Furthermore, UHRF1BP1 is thought to be a pivotal target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells.
Background References:
- Hopfner R, Mousli M, Jeltsch JM, et al. ICBP90, a novel human CCAAT binding protein, involved in the regulation of Topoisomerase IIα expression. Cancer Res. 2000; 60:121-8
- Unoki M, Nishidate T and Nakamura Y. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 2004; 23:7601-10.
- Karagianni P, Amazit L, Qin J, et al. ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol. Cell Biol. 2008; 28:705-17.
- Fang Z, Xing F, Bronner C, et al. ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells. Cell Immunol. 2009; 257:80-7.
Buffer:
UHRF1BP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
UHRF1BP1 antibody was raised against a 17 amino acid synthetic peptide near the center of human UHRF1BP1.
The immunogen is located within amino acids 890 - 940 of UHRF1BP1.
The immunogen is located within amino acids 890 - 940 of UHRF1BP1.
NCBI Gene ID #:
54887
NCBI Official Name:
UHRF1 binding protein 1
NCBI Official Symbol:
UHRF1BP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_060224
Protein GI Number:
134152667
Purification:
UHRF1BP1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
UHRF1BP1 antibody is predicted to not cross-react with UHRF1BP1L
Swissprot #:
Q6BDS2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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