NEUCRIN Antibody
| Code | Size | Price |
|---|
| PSI-6493-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6493-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NEUCRIN Antibody: UNQ3119, neucrin, AGPA3119, C1orf187, PSEC0258, UNQ3119/PRO10268, Draxin, Dorsal inhibitory axon guidance protein
Application Note:
Neucrin antibody can be used for detection of Neucrin by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
NEUCRIN Antibody: Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.
Background References:
- Islam SM, Shinmyo Y, Okafuji T, et al. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science 2009; 323:388-93.
- Miyake A, Takahashi Y, Miwa H, et al. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. Biochem. Biophys. Res. Commun. 2009; 390:1051-5.
- Ahmed G, Shinmyo Y, Naser IB, et al. Olfactory bulb axonal outgrowth is inhibited by draxin. Biochem. Biophys. Res. Commun. 2010; 398:730-4.
Buffer:
NEUCRIN Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (100%), Bovine: (100%)
Immunogen:
Neucrin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Neucrin.
The immunogen is located within the last 50 amino acids of NEUCRIN.
The immunogen is located within the last 50 amino acids of NEUCRIN.
NCBI Gene ID #:
374946
NCBI Official Name:
chromosome 1 open reading frame 187
NCBI Official Symbol:
DRAXIN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
BAG80561
Protein GI Number:
86990448
Purification:
NEUCRIN Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
Swissprot #:
Q8NBI3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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