Strumpellin Antibody
| Code | Size | Price |
|---|
| PSI-6497-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6497-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Strumpellin Antibody: RTSC, SPG8, WASH complex subunit strumpellin
Application Note:
Strumpellin antibody can be used for detection of Strumpellin by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Strumpellin Antibody: Strumpellin is a ubiquitously expressed, multi-transmembrane and spectrin-repeat-containing protein. It is named for Strumpell disease; a progressive upper-motor neurodegenerative disease termed hereditary spastic paraplegia (HSP). The Strumpellin gene maps to the eighth HSP locus (SPG8) on chromosome 8p24.13. Three families liked to this locus have mutations in the Strumpellin gene; rescue studies of zebrafish with decreased Strumpellin expression with Strumpellin mRNA containing these mutations showed impaired normal function of this protein. Recent studies suggest that Strumpellin may also be involved in protein aggregation diseases.
Background References:
- Valmanis PN, Meijer IA, Reynolds A, et al. Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia. Am. J. Hum. Gen. 2007; 80:152-61.
- Clemen CS, Tangavelou K, Strucksberg KH, et al. Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases. Brain 2010; 133:2920-41
Buffer:
Strumpellin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Strumpellin antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human Strumpellin.
The immunogen is located within the last 50 amino acids of Strumpellin.
The immunogen is located within the last 50 amino acids of Strumpellin.
NCBI Gene ID #:
9897
NCBI Official Name:
KIAA0196
NCBI Official Symbol:
KIAA0196
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055661
Protein GI Number:
120952851
Purification:
Strumpellin Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
Multiple isoforms of Strumpellin are known to exist.
Swissprot #:
Q12768
User NOte:
Optimal dilutions for each application to be determined by the researcher.
Related Products
| Product Name | Product Code | Supplier |
|---|