SDHAF2 Antibody

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ProSci
Product Code: PSI-6507
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-6507-0.02mg0.02mg£150.00
Quantity:
PSI-6507-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of SDHAF2 in rat liver tissue lysate with SDHAF2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Western blot analysis of SDHAF2 in rat liver tissue lysate with SDHAF2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

Documents

Further Information

Additional Names:
SDHAF2 Antibody: PGL2, SDH5, C11orf79, PGL2, Succinate dehydrogenase assembly factor 2, mitochondrial, Succinate dehydrogenase subunit 5, SDH assembly factor 2
Application Note:
SDHAF2 antibody can be used for detection of SDHAF2 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
SDHAF2 Antibody: SDHAF2 (Succinate dehydrogenase complex assembly factor 2) encodes a mitochondrial protein needed for FAD cofactor attach to the SDH enzyme which plays a critical role in mitochondria. SDHAF2 is a tumor suppressor, but recent evidence suggests that somatic mutations of the SDHAF2 are unlikely to contribute to parathyroid tumor development in sporadic primary hyperparathyroidism.
Background References:
  • Hao HX, Khalimonchuk O, Schraders M, et al. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 2009; 325:1139-42.
  • Burnichon N, Bri?re JJ, Lib? R, et al. SDHA is a tumor suppressor gene causing paraganglioma. Hum. Mol. Genet. 2010; 19:3011-20.
  • Kunst HP, Rutten MH, de Monnink JP, et al. SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma. Clin. Cancer Res. 2011; 17:247-54
  • Starker LF, Delgado-Verdugo A, Udelsman R, et al. Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism. Endocrine 2010; 38:397-401.
Buffer:
SDHAF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (93%)
Immunogen:
SDHAF2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SDHAF2.

The immunogen is located within the first 50 amino acids of SDHAF2.
NCBI Gene ID #:
54949
NCBI Official Name:
succinate dehydrogenase complex
NCBI Official Symbol:
SDHAF2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_060311
Protein GI Number:
8923450
Purification:
SDHAF2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
SDHAF2 antibody is predicted to not cross-react with other SDHAF protein family members.
Swissprot #:
Q9NX18
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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