DRGX Antibody
| Code | Size | Price |
|---|
| PSI-6517-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6517-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
DRGX Antibody: DRG11, PRRXL1, Dorsal root ganglia homeobox protein, Paired-related homeobox protein-like 1
Application Note:
DRGX antibody can be used for detection of DRGX by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
DRGX Antibody: DRGX, also known as DRG11 or PRRXL1, is a paired homeodomain transcription factor, and was initially cloned from a differential hybridization screen aimed at identifying dorsal root ganglia (DRG)-specific genes. DRGX is a key regulator of the differentiation of the spinal cord neuronal circuit dedicated to the processing of nociceptive information. DRGX is also important for the formation of the whisker-related somatosensory maps in the principal sensory nucleus of the trigeminal nerve, thalamus and somatosensory cortex.
Background References:
- Saito T, Greenwood A, Sun Q et al. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. Mol. Cell. Neurosci. 1995; 6:280-92.
- Chen ZF, Rebelo S, White F et al. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron 2001; 31:59-73.
- Ding YQ, Yin J, Xu HM, et al. Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11. J. Neurosci. 2003; 23:7246-54
- Rebelo S, Lopes C, Lima D, et al. Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system. Int. J. Dev. Biol. 2009; 53:1089-95.
Buffer:
DRGX Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DRGX antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human DRGX.
The immunogen is located within the last 50 amino acids of DRGX.
The immunogen is located within the last 50 amino acids of DRGX.
NCBI Gene ID #:
644168
NCBI Official Name:
dorsal root ganglia homeobox
NCBI Official Symbol:
DRGX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001073989
Protein GI Number:
122937484
Purification:
DRGX Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
At least two are known to exist; DRGX antibody is predicted to not cross-react with other Homeodomain proteins.
Swissprot #:
A6NNA5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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