ECRG1 Antibody
| Code | Size | Price |
|---|
| PSI-6521-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6521-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ECRG1 Antibody: ECRG1, ECRG1, HATL1, HESP, Transmembrane protease serine 11A, Airway trypsin-like protease 1
Application Note:
ECRG1 antibody can be used for detection of ECRG1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
ECRG1 Antibody: Epidermal type-II transmembrane serine protease (ECRG1), also known as TMPRSS11A, is a member of a novel esophageal cancer-related gene family. It is a type-II transmembrane serine protease which may play a role in cellular senescence. It is expressed in esophagus, liver, colon and lung. Overexpression of ECRG1 inhibits cell growth and induces G1 cell cycle arrest. It is down-regulated in esophagus cancers (EC) and might play important roles in the initiation and progression of EC.
Background References:
- Yueying W, Jianbo W, Hailin L, et al. ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors. Carcinogenesis 2008; 29:157-60.
- Zhao N, Wang J, Cui Y, et al. Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1. J. Cell Biochem. 2004; 92:65-76
- Zhao N, Huang G, Guo L, et al. ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. Exp. Biol. Med. 2006; 231:84-90.
Buffer:
ECRG1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ECRG1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG1.
The immunogen is located within amino acids 300 - 350 of ECRG1.
The immunogen is located within amino acids 300 - 350 of ECRG1.
NCBI Gene ID #:
339967
NCBI Official Name:
transmembrane protease, serine 11A
NCBI Official Symbol:
TMPRSS11A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q6ZMR5
Protein GI Number:
167466250
Purification:
ECRG1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
At least two isoforms of ECRG1 are known to exist; ECRG1 antibody is predicted to not cross-react with other ECRG family members.
Swissprot #:
Q6ZMR5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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