ECRG2 Antibody
| Code | Size | Price |
|---|
| PSI-6523-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6523-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ECRG2 Antibody: ECG2, ECRG2, ECG2, UNQ745/PRO1474, Serine protease inhibitor Kazal-type 7, Esophagus cancer-related gene 2 protein, ECRG-2
Application Note:
ECRG2 antibody can be used for detection of ECRG2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Background:
ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.
Background References:
- Cui Y, Wang J, Zhang X, et al. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. Biochem. Biophys. Res. Commun. 2003; 302:904-15.
- Huang G, Hu Z, Li M, et al. ECRG2 inhibits cancer cell migration, invasion and metastasis through the down-regulation of uPA/plasmin activity. Carcinogenesis 2007; 28:2274-81
- Cheng X, Shen Z, Yin L, et al. ECRG2 regulates cell migration/invasion through the urokinase-type plasmin activator receptor (uPAR)/beta1 integrin pathway. J. Biol. Chem. 2009; 284:30897-906
Buffer:
ECRG2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2.
The immunogen is located within the last 50 amino acids of ECRG2.
The immunogen is located within the last 50 amino acids of ECRG2.
NCBI Gene ID #:
84651
NCBI Official Name:
serine peptidase inhibitor, Kazal type 7
NCBI Official Symbol:
SPINK7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 9 kDa
Observed: 14 kDa
Observed: 14 kDa
Protein Accession #:
AAI09386
Protein GI Number:
14211875
Purification:
ECRG2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
ECRG2 antibody is predicted to not cross-react with other ECRG family members
Swissprot #:
P58062
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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