TGM7 Antibody
| Code | Size | Price |
|---|
| PSI-6541-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6541-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TGM7 Antibody: TGMZ, Protein-glutamine gamma-glutamyltransferase Z, Transglutaminase Z, TGZ
Application Note:
TGM7 antibody can be used for detection of TGM7 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TGM7 Antibody: Transglutaminases (TGM) are a family of structurally and functionally related Ca2+-dependent enzymes (TGases) that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. TGases influence numerous biological processes, including blood coagulation, cell differentiation, fertilization and apoptosis. TGM7 belongs to the transglutaminase superfamily and is also thought to catalyze the cross-linking of proteins, often resulting in stabilization of protein assemblies. Little is known of the role of TGM7, but defects in the highly related protein TGM5 are associated with acral peeling skin syndrome.
Background References:
- Ueki S, et al. Dual functions of transglutaminase in novel cell adhesion. J. Cell Sci. 1996; 109:2727-35
- Grenard P, Bates MK, and Aeschlimann D. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. J. Biol. Chem. 2001; 276:33066-78.
- Cassidy AJ, van Steensel MA, Steijlen PM, et al. A homozygous missense mutation in TGM7 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am. J. Hum. Genet. 2005; 77:909-17.
Buffer:
TGM7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TGM7 antibody was raised against a 13 amino acid synthetic peptide near the center of human TGM7.
The immunogen is located within amino acids 460 - 510 of TGM7.
The immunogen is located within amino acids 460 - 510 of TGM7.
NCBI Gene ID #:
116179
NCBI Official Name:
transglutaminase 7
NCBI Official Symbol:
TGM7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AF363393
Protein GI Number:
16445035
Purification:
TGM7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
TGM7 antibody is predicted to not cross-react with other TGase protein family members. At least two isoforms of TGM7 are known to exist; this antibody will recognize both isoforms.
Swissprot #:
Q96PF1
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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