RASSF6 Antibody
| Code | Size | Price |
|---|
| PSI-6543-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6543-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
RASSF6 Antibody: Ras association domain-containing protein 6
Application Note:
RASSF6 antibody can be used for detection of RASSF6 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
RASSF6 Antibody: RASSF family proteins are tumor suppressors that are frequently downregulated during the development of human cancer. RASSF6 (Ras association (RalGDS/AF-6) domain family member 6), a member of RASSF family, acts as a Ras effector protein / tumor suppressor. RASSF6 contains one Ras-associating domain and one SARAH domain. It is involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. Defects in RASSF6 may facilitate viral NFκ-B pathway and may play a vital role in infection.
Background References:
- Van der Weyden L, Adams DJ. The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim. Biophys. Acta 2007; 1776:58-85
- Allen NP, Donninger H, Vos MD, et al. RASSF6 is a novel member of the RASSF family of tumor suppressors. Oncogene 2007; 26:6203-11
- Ikeda M, Hirabayashi S, Fujiwara N, et al. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. Exp. Cell Res. 2007; 313:1484-95
Buffer:
RASSF6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (93%), Rat: (93%)
Immunogen:
RASSF6 antibody was raised against a 14 amino acid synthetic peptide near the center of human RASSF6.
The immunogen is located within amino acids 230 - 280 of RASSF6.
The immunogen is located within amino acids 230 - 280 of RASSF6.
NCBI Gene ID #:
166824
NCBI Official Name:
Ras association (RalGDS/AF-6) domain family member 6
NCBI Official Symbol:
RASSF6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_803876
Protein GI Number:
41393610
Purification:
RASSF6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
At least four isoforms of RASSF6 are known to exist. RASSF6 antibody is predicted to not cross-react with other RASSF family members.
Swissprot #:
Q6ZTQ3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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