SLC35D3 Antibody
| Code | Size | Price |
|---|
| PSI-6547-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6547-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SLC35D3 Antibody: FRCL1, bA55K22.3, FRCL1, Solute carrier family 35 member D3, Fringe connection-like protein 1
Application Note:
SLC35D3 antibody can be used for detection of SLC35D3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SLC35D3 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The novel protein SLC35D3 is highly homologous to SLC35D1 and SLC35D2, both of which transport UDP-glucuronic acid and UDP-N-acetylgalactosamine, suggesting that SLC35D3 is also involved in the transport of nucleotide sugars. It has been suggested that SLC35D3 regulates platelet dense granules, lysosome-related organelles which contain high concentrations of several biologically important low molecular weight molecules necessary for normal blood homeostasis.
Background References:
- Ishida N and Kawakita M. Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch. 2004; 447:768-75.
- Suda T, Kamiyama S, Suzuki M, et al. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. J. Biol. Chem. 2004; 279:26469-74.
- Chintala S, Tan J, Gautam R, et al. The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules. Blood 2007; 109:1533-40
Buffer:
SLC35D3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SLC35D3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SLC35D3.
The immunogen is located within the last 50 amino acids of SLC35D3.
The immunogen is located within the last 50 amino acids of SLC35D3.
NCBI Gene ID #:
340146
NCBI Official Name:
solute carrier family 35, member D3
NCBI Official Symbol:
SLC35D3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 46 kDa
Observed: 45 kDa
Observed: 45 kDa
Protein Accession #:
AAH87842
Protein GI Number:
56912198
Purification:
SLC35D3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
At least two isoforms of SLC35D3 are known to exist; this antibody will recognize both isoforms. SLC35D3 antibody is predicted to not cross-react with SLC35D1 or SLC35D2.
Swissprot #:
Q5M8T2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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