ANKLE1 Antibody
| Code | Size | Price |
|---|
| PSI-6607-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6607-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ANKLE1 Antibody: LEM3, LEMD6, ANKRD41, LEM3, Ankyrin repeat and LEM domain-containing protein 1, Ankyrin repeat domain-containing protein 41
Application Note:
ANKLE1 antibody can be used for detection of ANKLE1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
ANKLE1 Antibody: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. ANKLE1 (Ankyrin repeat and LEM domain containing 1) is a member of ankyrin repeat and LEM domain containing family. It is a potential single-pass membrane protein that contains ankyrin repeats and a Lem domain. Ankyrin repeats mediate protein-protein interactions and are among the most common structural motifs in known proteins. While the function of this protein is still under investigation, its gene locus has been associated with susceptibility to ovarian and breast cancer.
Background References:
- Lee KK and Wilson KL. All in the family: evidence for four new LEM-domain proteins Lem2 (NET-25), Lem3, Lem4 and Lem5 in the human genome. Symp. Soc. Exp. Biol. 2004; 56:329-39.
- Bolton KL, Tyrer J, Song H, et al. Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat. Genet. 2010; 42:880-4.
- Antoniou AC, Wang X, Fredericksen ZS, et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat. Genet. 2010; 42:885-92.
Buffer:
ANKLE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ANKLE1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ANKLE1.
The immunogen is located within the last 50 amino acids of ANKLE1.
The immunogen is located within the last 50 amino acids of ANKLE1.
NCBI Gene ID #:
126549
NCBI Official Name:
ankyrin repeat and LEM domain containing 1
NCBI Official Symbol:
ANKLE1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_689576
Protein GI Number:
168229256
Purification:
ANKLE1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
Two isoforms of ANKLE1 are known to exist. ANKLE1 antibody is predicted to not cross-react with ANKLE2
Swissprot #:
Q8NAG6
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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