ZGPAT Antibody
| Code | Size | Price |
|---|
| PSI-6611-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-6611-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZGPAT Antibody: ZIP, ZC3H9, GPATC6, GPATCH6, ZC3HDC9, KIAA1847, ZIP, Zinc finger CCCH-type with G patch domain-containing protein, G patch domain-containing protein 6
Application Note:
ZGPAT antibody can be used for detection of ZGPAT by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.
Background References:
- Li R, Zhang H, Yu W, et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009; 28:2763-6.
- Yu W, Li R, Gui B, et al. sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP. J. Biol. Chem. 2010; 285:14301-7.
Buffer:
ZGPAT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Sheep: (100%), Bovine: (100%)
Immunogen:
ZGPAT antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ZGPAT.
The immunogen is located within the last 50 amino acids of ZGPAT.
The immunogen is located within the last 50 amino acids of ZGPAT.
NCBI Gene ID #:
84619
NCBI Official Name:
zinc finger, CCCH-type with G patch domain
NCBI Official Symbol:
ZGPAT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_115916
Protein GI Number:
133925793
Purification:
ZGPAT Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
Multiple isoforms of ZGPAT are known to exist.
Swissprot #:
Q8N5A5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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