TLR8 Antibody
| Code | Size | Price |
|---|
| PSI-3271-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3271-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Documents
Further Information
Additional Names:
TLR8 Antibody: CD288, Toll-like receptor 8
Application Note:
TLR8 antibody can be used for detection of TLR8 by immunohistochemistry at 5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Immunohistochemistry in human and mouse samples. All other applications and species not yet tested.
Antibody validated: Immunohistochemistry in human and mouse samples. All other applications and species not yet tested.
Background:
TLR8 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848.
Background References:
- Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77
- Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76
- Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
- O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Buffer:
TLR8 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TLR8 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TLR8.
The immunogen is located within the first 50 amino acids of TLR8.
The immunogen is located within the first 50 amino acids of TLR8.
NCBI Gene ID #:
51311
NCBI Official Name:
toll-like receptor 8
NCBI Official Symbol:
TLR8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_619542
Protein GI Number:
20302168
Purification:
TLR8 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
At least three isoforms of TLR8 are known to exist. TLR8 antibody is predicted to not cross-react with other TLR protein family members
Swissprot #:
Q9NR97
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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